Description

Thymosin Beta-4 fragment, commonly designated as TB-500, represents a synthetic analogue of the active region derived from the naturally occurring thymosin beta-4 protein. The parent compound thymosin beta-4 is a 43-amino acid peptide with the sequence SDKPDMAEI EKFDKSKLKK TETQEKNPLP SKETIEQEKQ AGES, exhibiting a molecular weight of 4982 g/mol and an isoelectric point of 5.1. TB-500 specifically incorporates the actin-binding domain of thymosin beta-4, which plays a crucial role in regulating cellular structure and function through interaction with actin filaments. Research applications have demonstrated that TB-500 exhibits anti-fibrotic activity through inhibition of Akt signaling pathways, making it valuable for investigating cellular response mechanisms. The synthetic nature of TB-500 allows for consistent production and standardized research applications, with typical preparations available in 5mg concentrations for laboratory use.